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Here are two sources that explain how to formulate a PICO question:
BMJ How to Clarify a Clinical Question
Once you have the question formed, you can then search for the answer in a database. A good database to use for this is the PubMed PICO Tool since it is designed to work with your question. It works well for handheld and smartphone users with links to search tools and full-text articles available from the Health Sciences Library.
Other important medical databases to use for clinically-based answers are:
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